Natural Sesquiterpenoids as Cytotoxic Anticancer Agents

Author(s): Q.-F. Chen, Z.-P. Liu, F.-P. Wang

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 13 , 2011

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Sesquiterpenoids are a group of naturally occurring 15-carbon isoprenoid compounds that are mainly found in higher plants, microorganism and marine life. Many of them provided encouraging leads for chemotherapeutics. In this review, the sesquiterpenoids are classified according to the ring numbering system and the functional groups presented in the core structures as acyclic, mono-, bi-, and tricyclic derivatives, and a current overview of sesquiterpenoids as potential cytotoxic anticancer agents is provided.

Keywords: Anticancer, cancer, cytotoxicity, natural products, sesquiterpenoids, tumor, microorganism, chemotherapeutics, ED50, IC50, EC50, GI50

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Article Details

Year: 2011
Page: [1153 - 1164]
Pages: 12
DOI: 10.2174/138955711797655399
Price: $65

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