Reciprocal Interactions Between Wakefulness and Sleep Influence Global and Regional Brain Activity

Author(s): Vincenzo Muto, Laura Mascetti, Luca Matarazzo, Caroline Kusse, Ariane Foret, Anahita Shaffii-Le Bourdiec, Gilles Vandewalle, Derk Jan Dijk, Pierre Maquet

Journal Name: Current Topics in Medicinal Chemistry

Volume 11 , Issue 19 , 2011


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Abstract:

Reciprocal interactions between wakefulness and sleep substantially influence human brain function in both states of vigilance. On the one hand, there is evidence that regionally-specialized brain activity during wakefulness is modulated by the interaction between a local use-dependent buildup of homeostatic sleep pressure and circadian signals. On the other hand, brain activity during sleep, although mainly constrained by genuine sleep oscillations, shows wakedependent regionally-specific modulations, which are involved in the dissipation of local homeostatic sleep pressure and memory consolidation.

Keywords: Sleep, slow waves, spindles, REM sleep, circadian rhythms, cognition, memory, neuroimaging, circadian signals, memory consolidation, regional modifications of brain, homeostatic regulation, core components, posterior cingulate cortices

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Article Details

VOLUME: 11
ISSUE: 19
Year: 2011
Page: [2403 - 2413]
Pages: 11
DOI: 10.2174/156802611797470358
Price: $65

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