Neurogenesis in Alzheimers Disease: A Realistic Alternative to Neuronal Degeneration?

Rocio      E. Gonzalez-Castaneda; Alma      Y. Galvez-Contreras; Sonia      Luquin; Oscar      Gonzalez-Perez

Abstract

Neural stem cells (NSC) are cells that have the capacity to generate multiple types of differentiated brain cells. In conditions in which there is a loss of key functional cell groups, such as neurons, inducing or introducing neural stem cells to replace the function of those cells that were lost during the disease has the greatest potential therapeutic applications. Indeed, the achievement of one of the main objectives of various investigations is already on the horizon for some conditions, such as Alzheimers disease. It is not known whether impaired neurogenesis contributes to neuronal depletion and cognitive dysfunction in Alzheimers disease (AD). The results of the different investigations are controversial; some studies have found that neurogenesis is increased in AD brains, but others have not.

Keywords: Neurodegenerative disease, Alzheimer's Disease, neurogenesis, neural stem cells, cell death, pEGFR, EGFR, Endocytosis, Gefitinib, Endosomes, Lysosomes, Nucleus, NSCLC