Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor

Author(s): Jing Li, Huan Li, Lei Zhang

Journal Name: Letters in Drug Design & Discovery

Volume 8 , Issue 9 , 2011

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Abstract:

4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.

Keywords: Crystal structure, HMG-CoA reductase, hydrogenation, pravastatin, 4, 5, 6, 7-tetrahydropravastatin, Tetrahydropravastatin, Staphylococcus aureus, SARs, HMG-CoA, CHD, Atherosclerotic, LDL-C, rhabdomoylsis, Elemental analyses

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2011
Page: [884 - 888]
Pages: 5
DOI: 10.2174/157018011797200876
Price: $65

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