Cytotoxicity Study on Some Synthetic Aromatic Esters of 4-Demethyl-4-deoxypodophyllotoxin

Author(s): Juan-Juan Wang, Hong-Jin Han, Guang-Zhi Zeng, Hui Xu, Ning-Hua Tan.

Journal Name: Letters in Drug Design & Discovery

Volume 8 , Issue 9 , 2011

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To search for potential anti-cancer analogs, 16 aromatic esters of 4-demethyl-4-deoxypodophyllotoxin (6a-p) were synthesized and tested their cytotoxicity on six cancer cell lines. The results indicated that all derivatives showed potent cytotoxic activity against A-549 cell line with IC50 values of 0.00009-0.037 μg/mL.

Keywords: Aromatic ester, Cytotoxicity, Deoxypodophyllotoxin, Aromatic Esters, Podophyllotoxin, antiproliferative, antitumor, carboxylalkyl, MS, 1H NMR, HRMS, Reed-Muench method

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Article Details

Year: 2011
Page: [857 - 860]
Pages: 4
DOI: 10.2174/157018011797200849
Price: $65

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