Title: Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines
VOLUME: 8 ISSUE: 9
Author(s):Ashish Sharma, Tabreskhan Pathan, Rhea Mohan and C. S. Ramaa
Affiliation:Department of pharmaceutical Chemistry, Bharati Vidyapeeth's College of Pharmacy, Sector 8, C.B.D. Belapur, Navi Mumbai- 400614, Maharashtra, India.
Keywords:Breast cancer cell line, Cytotoxicity, Pyrazoles, Pyrazolines, Sulforhodamine B Assay, antitumor activity, radiotherapy, fluorine, antitubercular, antimalarial, nucleophilic centers, heterocycles, antidepressant, breast cancer, MCF7, vagal nerve
Abstract: Novel fluorine-containing pyrazolines (2a-2g) and pyrazoles (5a-5e) were synthesized and evaluated for their cytotoxicity in vitro in a panel of four human cancer cell lines using Sulforhodamine B (SRB) assay. Though the compounds showed varying degrees of cytotoxicity in different cell lines, it was noteworthy that the 4H pyrazoles (5a-5e) were distinguished by their potent and selective action against MCF7 breast cancer cell line.
