Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives

Author(s): Kamal Sweidan, Jorn Engelmann, Rajendra Joshi, Mohammad S. Mubarak, Mustafa M. El-Abadelah

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 8 , 2011

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The reaction of 1,3-dimethyl-5-bis(thioethyl)methylene barbituric acid (2) with various vic-diamines leads to the formation of the respective 1,3-diazamethylene barbiturate derivatives 3 (a-f) in high yields. Solid-state 13C-NMR, MS and IR spectral data were employed for the characterization of these compounds. Antimicrobial screening revealed that none of the newly synthesized compounds showed appreciable antibacterial activity.

Keywords: 5-bis(thioethyl)methylenebarbiturates, 1,3-diazamethylene barbiturates, 1,3-dimethylbarbituric acid, azaheterocycles, solid-state 13C-NMR, pyrimidine, trioxopyrimidine, nucleophilic, amines, alkylation

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Article Details

Year: 2011
Page: [603 - 605]
Pages: 3
DOI: 10.2174/157017811797249353
Price: $65

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