One-Pot Preparation of N,N'-Alkylidene Bisamide Derivatives Catalyzed by Silica Supported Magnesium Chloride (SiO2-MgCl2)

Author(s): Mohammad R.M. Shafiee

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 8 , 2011

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A highly efficient and simple procedure for the preparation of N,N'-alkylidene bisamides via one-pot threecomponent condensation reaction of phenyl acetylene/1-Hexyne, aromatic aldehyde and benzamide/acetamide in the presence of catalytic amount of silica supported magnesium chloride (SiO2-MgCl2) under thermal solvent-free conditions is described. All of the reactions proceeded in high yields and in relatively short reaction times.

Keywords: Amide, Heterogeneous catalyst, N, N'-alkylidene bisamide, Silica Supported Magnesium Chloride (SiO2-MgCl2), aldehydes, alkyne, purification, pharmacological, oxazine, bisamides

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Article Details

Year: 2011
Page: [562 - 567]
Pages: 6
DOI: 10.2174/157017811797249344
Price: $65

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