Facile Microwave-Promoted Knoevenagel Condensation and the Combination of Knoevenagel/ Michael addition Reaction in Aqueous Medium Containing Ionic Surfactant

Author(s): Mithu Saha, Jahar Dey, Kochi Ismail, Amarta K. Pal

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 8 , 2011

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A simple, efficient, environment-friendly and high yielding procedure is developed for the Knoevenagel condensation and the combination of Knoevenagel/ Michael addition reaction of various 1, 3-dicarbonyls and aryl aldehydes in an aqueous surfactant medium. The reaction can be dramatically improved under microwave-irradiation.

Keywords: 4-hydroxy coumarin, barbituric acid, dimedone, Knoevenagel condensation, microwave-irradiation, surfactant medium, Diels-Alder reaction, anti-inflammatory activities, antioxidant, silica gel

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Article Details

Year: 2011
Page: [554 - 558]
Pages: 5
DOI: 10.2174/157017811797249272
Price: $65

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