Anti-NMDA Receptor Encephalitis in Psychiatry

Author(s): Matthew S. Kayser, Josep Dalmau

Journal Name: Current Psychiatry Reviews
Continued as Current Psychiatry Research and Reviews

Volume 7 , Issue 3 , 2011


Anti-NMDA receptor encephalitis is an autoimmune disorder in which antibodies attack NMDA (N-methyl-Daspartate)-type glutamate receptors at central neuronal synapses. Symptoms include a highly characteristic set of neurologic deficits, but also prominent psychiatric manifestations that often bring mental health professionals into the course of care. Distinct phases of illness have become increasingly appreciated, and include a range of psychotic symptoms early in the course of the disease followed by more severe fluctuations in consciousness with neurologic involvement, and ultimately protracted cognitive and behavioral deficits. Young women are most commonly impacted and an ovarian teratoma is sometimes associated with the syndrome. Patients respond well to immunotherapy, but psychiatric symptoms can be challenging to manage. We provide an up to date review of this disorder and highlight the role of psychiatry in diagnosis, symptomatology, and treatment.

Keywords: NMDA, receptor, autoimmune, synapse, paraneoplastic, schizophrenia, paraneoplastic disorder, neurologic symptoms, hyperthermia, hypoventilation, hypersexuality, hyperphagia, hypersomnia, Amnesia, Corticosteriods

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Article Details

Year: 2011
Page: [189 - 193]
Pages: 5
DOI: 10.2174/157340011797183184
Price: $58

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