Transient Receptor Potential A1 Modulators

Author(s): Tim Strassmaier, Rajagopal Bakthavatchalam

Journal Name: Current Topics in Medicinal Chemistry

Volume 11 , Issue 17 , 2011

Become EABM
Become Reviewer
Call for Editor


TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.

Keywords: Transient receptor potential, TRP channel, TRPA1, pain, asthma, inflammatory, non-selective cation channels, broad spectrum of chemical irritants, endogenous inflammatory compounds, inflammation raises, therapeutic potential, agonists, antagonists, TRPA1 modulators, genomic analysis

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Page: [2227 - 2236]
Pages: 10
DOI: 10.2174/156802611796904915
Price: $65

Article Metrics

PDF: 13