Methods, Processes and Comparative Yield Economics for the Production of Antibodies and Recombinant Proteins

Author(s): William A. Paradise, Benjamin J. Vesper, Michael Babich, Michael D. Colvard, James A. Radosevich

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents

Volume 11 , Issue 3 , 2011


Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.

Keywords: Antibodies, antibody production, biosimilars, comparative economics, downstream processing, expression pathways, operational excellence, immunotherapeutics, monoclonal and polyclonal antibody production, process efficiency improvement, recombinant proteins, six-sigma, smart systems, therapeutic protein production, yield economics

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Article Details

Year: 2011
Page: [199 - 219]
Pages: 21
DOI: 10.2174/187152211796642783
Price: $58

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