Potential Application of Dietary Polyphenols from Red Wine to Attaining Healthy Ageing

Author(s): T. Magrone, E. Jirillo

Journal Name: Current Topics in Medicinal Chemistry

Volume 11 , Issue 14 , 2011

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Polyphenols are ubiquitous compounds present in the vegetal kingdom and endowed with an array of beneficial activities to human health. In this review, the effects of dietary polyphenols on the prevention and/or mitigation of cancer, neurodegenerative diseases, obesity, metabolic syndrome and atherosclerosis will be illustrated. Moreover, emphasis will be placed on our own data concerning the in vitro effects performed by polyphenols from an italian red wine “Negroamaro” on human healthy peripheral blood mononuclear cells. Particularly, production of nitric oxide and maintenance of the inflammatory/anti-inflammatory cytokine network will be discussed also in relation to potential application to human age-related diseases. In conclusion, polyphenols in virtue of the plethora of protective effects manifested in various experimental models and clinical trials seem to be appropriate as dietary supplements for preventing the functional decline of organs with age.

Keywords: Age-related diseases, immunity, polyphenols/kwd, >, prevention, wine, cancer, neurodegenerative diseases, obesity, metabolic syndrome, atherosclerosis, nitric oxide, dementia

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Article Details

Year: 2011
Page: [1780 - 1796]
Pages: 17
DOI: 10.2174/156802611796235116
Price: $65

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