In this study, 2-chloroquinolin-3-carbaldehyde 1 was used as a synthon for the synthesis of some new quinoline; pyrane; indeno[1,2-b]pyrano[2,3-b]quinoline heterocycles. The anti-inflammatory and analgesic activities of the synthesized compounds were evaluated using carrageenan-induced paw edema and writhing assays. The obtained data indicated that the majority of the tested compounds exhibited both analgesic and anti-inflammatory activities, particularly compounds 2 and 6 showed a comparable effect to a well known analgesic and anti-inflammatory, diclofenac sodium.
Keywords: Quinoline, Pyranes, Knoevenagel reaction, Analgesic, Anti-inflammatory, X-ray analysis, heterocyclic compounds, 2-chloroquinolin-3-carbaldehydes, synthon, benzoylacetonitrile, NMR spectrum, hot plate test, X-Ray Crystallography, water ad libitum, pyrazole residues
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