Abstract
Electrophilic amination constitutes a unique strategy for the synthesis of C – N bonds. One often-overlooked example of this type of process involves the reaction of organometallic nucleophiles with electrophilic nitrogen sources to yield aryl and alkyl amine derivatives. Such transformations are mechanistically intriguing and have the potential to drastically alter the logic by which nitrogencontaining compounds are synthesized.
Keywords: Amination, C, –, N bonds, electrophilic nitrogen, mechanism, organometallic reagents, umpolung
Mini-Reviews in Organic Chemistry
Title: Electrophilic Amination of Organometallic Reagents: Recent Discoveries and Mechanistic Insights
Volume: 8 Issue: 3
Author(s): David E. Olson
Affiliation:
Keywords: Amination, C, –, N bonds, electrophilic nitrogen, mechanism, organometallic reagents, umpolung
Abstract: Electrophilic amination constitutes a unique strategy for the synthesis of C – N bonds. One often-overlooked example of this type of process involves the reaction of organometallic nucleophiles with electrophilic nitrogen sources to yield aryl and alkyl amine derivatives. Such transformations are mechanistically intriguing and have the potential to drastically alter the logic by which nitrogencontaining compounds are synthesized.
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Cite this article as:
E. Olson David, Electrophilic Amination of Organometallic Reagents: Recent Discoveries and Mechanistic Insights, Mini-Reviews in Organic Chemistry 2011; 8 (3) . https://dx.doi.org/10.2174/157019311796197391
DOI https://dx.doi.org/10.2174/157019311796197391 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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