Title: Intraocular Immune Mechanisms in Uveitis
VOLUME: 7 ISSUE: 3
Author(s):S. John Curnow, Alastair K.O. Denniston, Philip I. Murray and Graham R. Wallace
Affiliation:Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Keywords:Uveitis, inflammation, cytokines, chemokines, autoimmune, Intraocular Immune Mechanisms, blood-ocular barriers, ocular microenvironment, Toxoplasma gondii, HLA-B27
Abstract: Uveitis describes a group of sight threatening disorders characterized by breakdown of the blood-ocular barriers, cellular infiltration and tissue damage. Uveitis can be categorized into different groups based on site of inflammation in the eye, the onset, duration and course of disease, and causative agent. Whether these different forms of uveitis have different aetiologies is of interest with regards to prognosis and therapy in individual patients. In this review, we shall discuss mechanisms of blood-ocular barrier breakdown, cellular responses and the molecules involved in different uveitis conditions.
