Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging

Author(s): Shuanglong Liu, Bin Shen, Frederick T. Chin, Zhen Cheng

Journal Name: Current Organic Synthesis

Volume 8 , Issue 4 , 2011

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Because of its low positron energy, lack of side emission, and a moderate half-life, Fluorine-18 (β+, 0.635 MeV [97%], t1/2 = 109.8 min) has ideal physical properties for positron emission tomography (PET). With the increasing numbers of peptides that are potentially applicable for molecular imaging of diseases, novel and simple 18F-labeling methods have been actively investigated and reported. In this review, a few well established and widely-used radiofluorination strategies are discussed. Novel approaches including click chemistry, one-step chelation labeling (i.e. Al18F-NOTA), and silicon-based 18F labeling are described as well.

Keywords: 18F, Radiofluorination, Positron emission tomography, Peptide, Molecular Imaging, SPECT, chelation labeling, click reaction, HPLC

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Article Details

Year: 2011
Page: [584 - 592]
Pages: 9
DOI: 10.2174/157017911796117197
Price: $65

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