Molecular Probes for Bioluminescence Imaging

Author(s): Song Wu, Edwin Chang, Zhen Cheng

Journal Name: Current Organic Synthesis

Volume 8 , Issue 4 , 2011

Become EABM
Become Reviewer
Call for Editor


Bioluminescence refers to the emission of light from a living system in which photoproteins such as luciferase enzymes oxidize their substrates to produce light. Because of its high-sensitivity and low-toxicity, bioluminescence imaging (BLI) is particularly useful for in vitro assays and in vivo small animal imaging. It provides a powerful tool to study various important biological questions and processes including gene and protein expression, protein-protein interactions, protein-nucleic acid interactions, and cell signaling pathway functions. This review highlights some of the latest developments in the design and applications of molecular probes for BLI.

Keywords: Bioluminescence imaging, Molecular Imaging, Probe, Luciferase, Bioluminescence Resonance Energy Transfer, MRI, Luciferase Mutugenesis, D-luciferin Analogs, Luciferase Fused Proteins, Intramolecular Enzyme Complementation

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Page: [488 - 497]
Pages: 10
DOI: 10.2174/157017911796117188
Price: $65

Article Metrics

PDF: 4