Abstract
Human adult skeletal stem cells, a.k.a. mesenchymal stem cells or marrow stromal cells (MSCs), have been identified as precursors of several different mesenchymal cellular lineages, including osteoblasts, chondrocytes, myoblasts, adipocytes, and fibroblasts, as well as non-mesenchymal lineages including neurons and glial cells. Adult stem cell transplantation is a promising strategy for the treatment of stroke. MSCs are also used as a platform for gene therapies and therapeutic agents. In this review, we discuss recent progress of human skeletal stem cell biology, in vitro differentiation of MSCs into neural stem cells and neurons, MSC therapy for stroke, MSC aging and the challenge of autologous cell therapy for stroke in elderly patients.
Keywords: Cell therapy, elderly patients, human skeletal stem cells, MSCs, aging, stroke, mesenchymal stem cells, marrow stromal cells, gene-modified MSCs, neurons, neural stem cells, Adult stem cell transplantation, gene therapy, stem cell aging, stem cell biology, autologous cell therapy, neurogenesis, A brief history of MSCs, the origin of mesenchymal stem cells, differentiation, ICH, Ischemic stroke, CNS, trophic factor, Clinical trials
Central Nervous System Agents in Medicinal Chemistry
Title: From Bone to Brain: Human Skeletal Stem Cell Therapy for Stroke
Volume: 11 Issue: 2
Author(s): Shuanhu Zhou
Affiliation:
Keywords: Cell therapy, elderly patients, human skeletal stem cells, MSCs, aging, stroke, mesenchymal stem cells, marrow stromal cells, gene-modified MSCs, neurons, neural stem cells, Adult stem cell transplantation, gene therapy, stem cell aging, stem cell biology, autologous cell therapy, neurogenesis, A brief history of MSCs, the origin of mesenchymal stem cells, differentiation, ICH, Ischemic stroke, CNS, trophic factor, Clinical trials
Abstract: Human adult skeletal stem cells, a.k.a. mesenchymal stem cells or marrow stromal cells (MSCs), have been identified as precursors of several different mesenchymal cellular lineages, including osteoblasts, chondrocytes, myoblasts, adipocytes, and fibroblasts, as well as non-mesenchymal lineages including neurons and glial cells. Adult stem cell transplantation is a promising strategy for the treatment of stroke. MSCs are also used as a platform for gene therapies and therapeutic agents. In this review, we discuss recent progress of human skeletal stem cell biology, in vitro differentiation of MSCs into neural stem cells and neurons, MSC therapy for stroke, MSC aging and the challenge of autologous cell therapy for stroke in elderly patients.
Export Options
About this article
Cite this article as:
Zhou Shuanhu, From Bone to Brain: Human Skeletal Stem Cell Therapy for Stroke, Central Nervous System Agents in Medicinal Chemistry 2011; 11 (2) . https://dx.doi.org/10.2174/187152411796011376
DOI https://dx.doi.org/10.2174/187152411796011376 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Use of Fullerenes in Cosmetics
Recent Patents on Biotechnology Multimodality Imaging of CXCR4 in Cancer: Current Status towards Clinical Translation
Current Molecular Medicine Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases
Current Drug Targets Cholinesterases and Cholinesterase Inhibitors
Current Enzyme Inhibition Transendothelial Migration of Monocytes: The Underlying Molecular Mechanisms and Consequences of HIV-1 Infection
Current HIV Research Functional Food with Some Health Benefits, So Called Superfood: A Review
Current Nutrition & Food Science The Application of Freidinger Lactams and their Analogs in the Design of Conformationally Constrained Peptidomimetics
Current Medicinal Chemistry Novel Circular, Cyclic and Acyclic ψ(CH2O) Containing Peptide Inhibitors of SKI- 1/S1P: Synthesis, Kinetic and Biochemical Evaluations
Current Medicinal Chemistry Genetically Engineered Stem Cells for Therapeutic Gene Delivery
Current Gene Therapy Peripheral Immune Signatures in Alzheimer Disease
Current Alzheimer Research Editorial: Neurodegenerative Disorders: Synthesis, Drug Delivery Strategies and Biological Evaluation of New Therapeutic Agents
Central Nervous System Agents in Medicinal Chemistry The Role of Toll-Like Receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A New Promising Therapeutic Approach?
CNS & Neurological Disorders - Drug Targets Diabetes Mellitus to Neurodegenerative Disorders: Is Oxidative Stress Fueling the Flame?
CNS & Neurological Disorders - Drug Targets Extracellular Level of GABA and Glu: In Vivo Microdialysis-HPLC Measurements
Current Topics in Medicinal Chemistry Induced Pluripotent Stem Cell-Based Studies of Parkinson's Disease: Challenges and Promises
CNS & Neurological Disorders - Drug Targets A Translational View of Peptide Treatment of Neurological Disorders
Current Medicinal Chemistry The Bioanalytical Molecular Pharmacology of the N-methyl-<sub>D</sub>-Aspartate (NMDA) Receptor Nexus and the Oxygen-Responsive Transcription Factor HIF-1α : Putative Mechanisms and Regulatory Pathways Unravel the Intimate Hypoxia Connection
Current Molecular Pharmacology Editorial: “Phytochemicals for Human Diseases: An Update”
Current Drug Targets Oxidative Stress and Antioxidants in Carcinogenesis and Integrative Therapy of Cancer
Current Pharmaceutical Design The Role of IRE1 Signaling in the Central Nervous System Diseases
Current Neuropharmacology