Design, Synthesis of Novel Quinazolone Alkaloids Derivatives as Potential Antitumor Agents

Author(s): Youguang Zheng, Min Sun, Yi Liu, Mingdong Li, Min Ji

Journal Name: Medicinal Chemistry

Volume 7 , Issue 4 , 2011


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Abstract:

Several novel quinazolone alkaloids derivatives were synthesized. Some of the target compounds were determined against human prostate cancer DU145 and pancreatic cancer Miacapa2 cells in vitro. The entire compounds had been identified by 1HNMR, 13CNMR, IR, MS and EA.

Keywords: Quinazolone alkaloids, human pancreatic cancer, Miacapa2, EGFR, X-ray crystal structure, prostate cancer, EA, MS, IR, 13CNMR, 1HNMR

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2011
Published on: 01 March, 2012
Page: [295 - 300]
Pages: 6
DOI: 10.2174/157340611796150987
Price: $65

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