Synthesis and DPPH Radical Scavenging Activity of 5-Arylidene-N,Ndimethylbarbiturates

Author(s): Khalid Mohammed Khan, Momin Khan, Muhammad Ali, Muhammad Taha, Abdul Hameed, Sajjad Ali, Shahnaz Perveen, M. Iqbal Choudhary

Journal Name: Medicinal Chemistry

Volume 7 , Issue 3 , 2011

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Abstract:

Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.

Keywords: DPPH Radical scavengers, N,N-dimethylbarbiturates, N,N-dimethylbarbituric acid, DPPH, scavenging activity, antioxidant, spectroscopic techniques, elemental analysis, Barbituric acid, n-propyl gallate

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2011
Page: [231 - 236]
Pages: 6
DOI: 10.2174/157340611795564231
Price: $65

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