Advances in the Synthesis of A-Ring 1,7-Enyne Synthons for Active Vitamin D3 Analogues

Author(s): Yi-Zhen Yin, Jian-Ping Li, Chao Liu, Long-Qian Tang, Zhao-Peng Liu

Journal Name: Current Organic Synthesis

Volume 8 , Issue 3 , 2011

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In the past ten years, the development of efficient methods for the synthesis of A-ring 1,7-enyne synthons is one of the most fascinating aspects in the area of active vitamin D3 research. Many concise and practical approaches to construct A-ring 1,7-enyne fragments have been developed, leading to the synthesis of numerous biologically interesting vitamin D3 derivatives, differing in both stereochemistry and substituents in the A-ring portion of 1α,25-dihydroxyvitamin D3. In this review, synthetic methods of A-ring 1,7-enyne synthons, including modifications at the 1-, 2-, 3- and 4-positions of the vitamin D A-ring system, will be fully introduced.

Keywords: 1α,25-dihydroxyvitamin D3, vitamin D, A-ring precursors, 1,7-enyne, synthon, palladium, coupling, synthesis, chemistry, homeostasis

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Article Details

Year: 2011
Page: [374 - 392]
Pages: 19
DOI: 10.2174/157017911795529074
Price: $65

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