The First Total Synthesis of Tarennane, a Potent Antioxidant Chalcone Constituent from Tarenna Attenuate or Magnolia Officinalis

Author(s): Jincheng Yang, Tao Yang, Youfu Luo, Jun He, Jianyou Shi, Aihua Peng

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 4 , 2011

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The convergent total synthesis of tarennane has been accomplished in six steps starting from commercially available phloroglucinol and guaiacol; the key step of the synthesis relies on a highly regioselective Heck reaction applying iodophenol and PdCl2(PPh3)2.

Keywords: Tarennane, total synthesis, heck reaction, antioxidant activity, Helicobacter pylori, Alpinia rafflesiana, Cardamonin, ketone, Magnolianone, tetrabutylammonium

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Article Details

Year: 2011
Page: [258 - 263]
Pages: 6
DOI: 10.2174/157017811795371368
Price: $65

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