Salicylanilides and Their Derivates as Perspective Anti-tuberculosis Drugs: Synthetic Routes and Biological Evaluations

Author(s): Ales Imramovsky, Karel Pauk, Vladimir Pejchal, Jiri Hanusek

Journal Name: Mini-Reviews in Organic Chemistry

Volume 8 , Issue 2 , 2011

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Salicylanilides are a well-known family of pharmacological compounds, which are under renewed investigation because of the discovery of novel interesting biological activities and mechanisms of action over the last decade. This comprehensive mini-review describes the biological and pharmacological properties of salicylanilides, their activity against atypical and multi-drug resistant mycobacterial strains, and synthetic routes for their preparation. In particular, this review focuses on the synthesis and biological properties of salicylanilides and O-substituted derivates reported between 2000 and 2010, which have displayed the highest antituberculosis or antifungal activity.

Keywords: Anti-MDR tuberculotics, anti-tuberculotic agents, hydroxybenzamides, salicylanilides, salicylanilide derivates, pharmacological compounds, antifungal, antimicrobial

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Article Details

Year: 2011
Page: [211 - 220]
Pages: 10
DOI: 10.2174/157019311795177808
Price: $65

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