Efficient One-Pot Formation of Substituted γ-Amino Acids

Author(s): Mardia T. El-Sayed, Muhammad Abbas, Andreas Hilgeroth

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 5 , 2011

Become EABM
Become Reviewer
Call for Editor


A series of novel substituted γ-amino acids has been catalytically prepared by a one-pot reaction of substituted imines and homoenolates. The efficiency of the novel direct route has been found to depend on the nature of amine being either aliphatic or aromatic. Additionally, the influence of aromatic substituents has been investigated.

Keywords: γ-amino acid, homoenolate, imines, lewis acid, peptidases, homoaldol reaction, hydroxy, carbonyl, biodegradation, homoenolates

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Page: [320 - 324]
Pages: 5
DOI: 10.2174/157017811795685081
Price: $65

Article Metrics

PDF: 5