Efficient One-Pot Formation of Substituted γ-Amino Acids

Title: Efficient One-Pot Formation of Substituted γ-Amino Acids

Volume: 8 Issue: 5

Author(s): Mardia T. El-Sayed, Muhammad Abbas and Andreas Hilgeroth

Affiliation:

Keywords: γ-amino acid, homoenolate, imines, lewis acid, peptidases, homoaldol reaction, hydroxy, carbonyl, biodegradation, homoenolates

Abstract: A series of novel substituted γ-amino acids has been catalytically prepared by a one-pot reaction of substituted imines and homoenolates. The efficiency of the novel direct route has been found to depend on the nature of amine being either aliphatic or aromatic. Additionally, the influence of aromatic substituents has been investigated.

Cite this article as:

T. El-Sayed Mardia, Abbas Muhammad and Hilgeroth Andreas, Efficient One-Pot Formation of Substituted γ-Amino Acids, Letters in Organic Chemistry 2011; 8 (5) . https://dx.doi.org/10.2174/157017811795685081