Title: Black Light Induced Radical Cyclization Approach to Cyclonucleosides: An Independent Approach
VOLUME: 8 ISSUE: 5
Author(s):Victoria T. Perchyonok
Affiliation:VTPCHEM PTY LTD, Melbourne, 3163, Australia
Keywords:Cyclo-nucleosides, black light, aqueous media, free radical reactions, dihydrothymidine, deoxyribose, chromatographic, diastereoisomers, oligonucleotides, cyclopyrimidine
Abstract: The paper highlights an efficient methodology based on consecutive radical reaction for the preparation of cyclonucleoside derivatives. The reactions were performed in organic and aqueous media, using common and efficient free radical hydrogen donors in the range of innovative and conventional initiation conditions to afford good to excellent yields of corresponding cyclonucleosides. The mechanistic aspects of the transformations are also addressed.
