Synthesis of 5-arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-arylmethyl-5-phenyl-2-thioxoimidazolidin-4- one) via the reaction of 3-aryl-2,3-epoxyl-1-phenyl-1-propanone and urea (or thiourea) was carried out in 57-98% yields at 50 °C in EtOH in the presence of KOH under ultrasound irradiation. The procedure has the advantages of mild conditions, short reaction time and high yield.
Keywords: Substituted hydantoin, synthesis, chalcone oxide, ultrasound irradiation, seizures, convulsions, epoxyl, methoxyphenyl, propanone, imidazolidine
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Published on: 01 March, 2012
Page: [198 - 201]