Erbin, a Negative Regulator in Diverse Signal Pathways

Author(s): Dan Liu, Ming Shi, Huijun Duan, Caili Han, Ning Guo

Journal Name: Current Protein & Peptide Science

Volume 11 , Issue 8 , 2010

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Erbin belongs to the LAP protein family. Originally, Erbin was described as a Her2-interacting protein. Recent studies demonstrated that Erbin could inhibit the Ras-mediated activation of the mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB) and transforming growth factor β (TGF-β) signaling pathways. It suggests that Erbin may function as a signaling molecule. The functions of Erbin in determining cell polarity and cell adhesion have been well described. This review mainly focuses on the recent findings in regulation of signaling pathways by Erbin.

Keywords: Erbin, MAPK, ERK, NF-κB, TGF-β, signal transduction, carbonyl termini, epithelial morphogensis, mutagenesis, velocardiofacial syndrome, down regulation

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [759 - 764]
Pages: 6
DOI: 10.2174/138920310794557673
Price: $65

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