Synthesis and Biological Evaluation of a Range of Thiosemicarbazone - Based Compounds as Potential Inhibitors of Estrone Sulfatase (ES)

Author(s): Amit Kumar, Sukriti Singh, Hadi Bordbar, Timothy Cartledge, Sabbir Ahmed

Journal Name: Letters in Drug Design & Discovery

Volume 8 , Issue 3 , 2011

Become EABM
Become Reviewer
Call for Editor


We report the initial results of our study into a series of thiosemicarbazone-based compounds as potential inhibitors of estrone sulfatase (ES). The results show the compounds to be weak inhibitors of ES in comparison to the standard estrone-3-O-sulfamate used within the study and which possessed 98% inhibition under similar conditions.

Keywords: Estrone sulfatase, Inhibition, Breast cancer, Thiosemicarbazones, Non-steroidal, Non-competitive inhibition

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Page: [241 - 245]
Pages: 5
DOI: 10.2174/157018011794578231
Price: $65

Article Metrics

PDF: 3