The Global Component-Target Network in Panax Ginseng C

Fan      Zhang; Chun-Yang      Li; En-Qin      Wang; Wen-Wen      Li; Qi-Jia      Yu; Xin      Wen; Jun-Jie      Liu; Jin-Ku      Bao

Abstract

Panax ginseng C. A. Meyer (PG), a well-known traditional Chinese medicine, has been widely used as a panacea in treatment of human diseases for a long time. In this study, we exerted systems biology and bioinformatics methods for the first time and analyzed the “giant components” of PG in the global component-target interaction network. Based upon this network, we further confirmed several key components and their related targets (e.g., NF-κB, COX-2, Bax, NOS, JNK, p21 and MMP3). Additionally, we demonstrated that ginsenosides and key targets were involved in several cancer-related pathways, which indicated that ginsenosides might play crucial roles in cancer treatments. Interestingly, we also found that the component-target network might provide new clues for further predicting new targets and elucidating the relationships amongst the network and side-effects. In conclusion, these inspiring findings demonstrate that the versatile effects of PG are mostly ascribed to the comprehensive interactions amongst ginsenosides and their pivotal targets.

Keywords: Panax ginseng C. A. Meyer, Ginsenoside, Network, NF-B, Cancer, Drugs, bioinformatics, phytosterols, peptides, polysaccharides, fatty acids, polyacetylenes, vitamins, minerals, Cytoscape, cytokines, ultraviolet irradiation, heat shock, osmotic shock, Matrix metalloproteinase-3, immunoregulation, Bcl-2-associated X protein, Traditional Chinese Medicine, c-Jun N-terminal kinases, Nuclear Factor kappa B, Cyclin-dependent kinase inhibitor 1