Title: Heterocyclic Compounds as MDR Modulators
VOLUME: 8 ISSUE: 2
Author(s):Gyorgy Hajos, Katalin Jemnitz, Zsuzsanna Riedl, Daniella Takacs and Zsuzsa Veres
Affiliation:Institute of Biomolecular Chemistry, Chemical Research Center of the Hungarian Academy of Sciences, Pusztaszeri ut 59, H-1025 Budapest, Hungary.
Keywords:MDR modulation, Heterocyclic, Imidazole, Quinoline, Tetrahydroisoquinoline, Phenothiazine, multidrug resistance (MDR), Pglycoprotein (P-gp), protozoan parasite, Nbenzylpiperazine, doxorubicin, 99mTc-tetrofosmin, fluorescence activity, paclitaxel, vincristine, colon carcinoma, cruciferous vegetables, fumitremorgin, mitoxanthrone, tissue polypeptide antigen-A, rhodamine, cyclosporine, tariquidar, anthranylamine, zosuquidar, severe combined immunodeficient (SCID), C6 glioblastoma cell, clomipramine, piperazine, dioxaphosphinane
Abstract: A survey on MDR modulators containing heterocyclic moiety in the chemical structure for the past 20 years is provided. The discussion of the particular active compound is classified according to the heterocyclic rings involved. The most important biological results are also summarized.
