Abstract
We review the most recent findings on human filamin structure, with particular emphasis on the relationships between structure, function, and interaction. Filamin is a cytoskeletal actin-binding protein and it is therefore crucial in providing cells with the necessary mechanical and dynamical properties. Filamentous actin cross-linking by filamin is regulated by a number of other proteins and the molecular mechanisms of this complex interaction network can be understood by highlighting the structural features of isolated filamin moieties and of their complexes with several partners. Here we describe first the structure-function relationships of the isolated filamin, its flexibility, and its dimerization mechanism. Secondly, we illustrate the structural mechanism with which filamin can recognize its partners, both the actin filaments and the regulatory proteins.
Keywords: Filamin, actin, actin-binding proteins, cystoskeleton, Z-disk, cytoskeletal actin-binding protein, cell's internal scaffold, chromosome separation, mitosis, meiosis, acto-myosin system, actinin, spectrin, N-terminal actin binding domain (ABD), calponin homology domains (CH), immunoglubulin-like domains, Dictyostelium discoideum filamin, mammalian filamin, FLNA, FLNB, FLNC, tumor necrosis, calcium-sensing receptor, glycoprotein Ib, pacemaker channel HCN1, dopamine D2, glutamate receptor type 7, calcitonin re-ceptor, potassium channel, integrin 7, to, myotilin, sarcolemma, transmembrane receptors, adapter proteins, myofibrillar myopathies, ectopic sites, Dimerization, Dictyostelium discoideum, C-Terminal Rod 2 Domains, N-Terminal Rod 1 Domains, Promiscuity and Fidelity
Current Protein & Peptide Science
Title: Structural Portrait of Filamin Interaction Mechanisms
Volume: 11 Issue: 7
Author(s): Kristina Djinovic-Carugo and Oliviero Carugo
Affiliation:
Keywords: Filamin, actin, actin-binding proteins, cystoskeleton, Z-disk, cytoskeletal actin-binding protein, cell's internal scaffold, chromosome separation, mitosis, meiosis, acto-myosin system, actinin, spectrin, N-terminal actin binding domain (ABD), calponin homology domains (CH), immunoglubulin-like domains, Dictyostelium discoideum filamin, mammalian filamin, FLNA, FLNB, FLNC, tumor necrosis, calcium-sensing receptor, glycoprotein Ib, pacemaker channel HCN1, dopamine D2, glutamate receptor type 7, calcitonin re-ceptor, potassium channel, integrin 7, to, myotilin, sarcolemma, transmembrane receptors, adapter proteins, myofibrillar myopathies, ectopic sites, Dimerization, Dictyostelium discoideum, C-Terminal Rod 2 Domains, N-Terminal Rod 1 Domains, Promiscuity and Fidelity
Abstract: We review the most recent findings on human filamin structure, with particular emphasis on the relationships between structure, function, and interaction. Filamin is a cytoskeletal actin-binding protein and it is therefore crucial in providing cells with the necessary mechanical and dynamical properties. Filamentous actin cross-linking by filamin is regulated by a number of other proteins and the molecular mechanisms of this complex interaction network can be understood by highlighting the structural features of isolated filamin moieties and of their complexes with several partners. Here we describe first the structure-function relationships of the isolated filamin, its flexibility, and its dimerization mechanism. Secondly, we illustrate the structural mechanism with which filamin can recognize its partners, both the actin filaments and the regulatory proteins.
Export Options
About this article
Cite this article as:
Djinovic-Carugo Kristina and Carugo Oliviero, Structural Portrait of Filamin Interaction Mechanisms, Current Protein & Peptide Science 2010; 11 (7) . https://dx.doi.org/10.2174/138920310794109111
DOI https://dx.doi.org/10.2174/138920310794109111 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Manipulating Intracellular Ca2+ Signals to Stimulate Therapeutic Angiogenesis in Cardiovascular Disorders
Current Pharmaceutical Biotechnology Biological Evaluation of Fluorinated p-Boronophenylalanine Derivatives as a Boron Carrier
Protein & Peptide Letters Peptide Sequence-Dominated Enzyme-Responsive Nanoplatform for Anticancer Drug Delivery
Current Topics in Medicinal Chemistry Novel Molecular Anti- Colorectalcancer Conjugate:Chlorambucil-Adipic Acid Dihydrizide-Glutamine
Anti-Cancer Agents in Medicinal Chemistry The Water Channels, New Druggable Targets to Combat Cancer Cell Survival,Invasiveness and Metastasis
Current Drug Targets Anti-Inflammatory Activity of Tetracyclines: Applications to Human Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Cytochrome P450-Mediated Estrogen Metabolites and Autoimmunity: Relationship and Link to Free Radicals
Current Drug Metabolism Noscapine-loaded PLA Nanoparticles: Systematic Study of Effect of Formulation and Process Variables on Particle Size, Drug Loading and Entrapment Efficiency
Pharmaceutical Nanotechnology The Endoplasmic Reticulum Alpha-Glycosidases as Potential Targets for Virus Control
Current Protein & Peptide Science Lifestyle Factors and MicroRNAs: A New Paradigm in Cancer Chemoprevention
MicroRNA Lumiflavin Enhances the Effects of Ionising Radiation on Ovarian Cancer Stem-Like Cells by Inhibiting Autophagy
Anti-Cancer Agents in Medicinal Chemistry A Review: Hair Health, Concerns of Shampoo Ingredients and Scalp Nourishing Treatments
Current Pharmaceutical Biotechnology Polyethylenimine-based Formulations for Delivery of Oligonucleotides
Current Medicinal Chemistry Cell Death in Mammalian Development
Current Pharmaceutical Design The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases
Current Molecular Pharmacology Molecular and Biological Functions of Melatonin in Endometrial Cancer
Current Drug Targets Regulation of Innate Immune Responses in the Central Nervous System
CNS & Neurological Disorders - Drug Targets Ribozymes in the Age of Molecular Therapeutics
Current Molecular Medicine Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2- oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives
Letters in Drug Design & Discovery Synthesis and in vitro Evaluation of the Anticancer Potential of New Aminoalkanol Derivatives of Xanthone
Anti-Cancer Agents in Medicinal Chemistry