Synthesis and Evaluation of Antimicrobial Activity of Thiazolidinone Derivatives

Title: Synthesis and Evaluation of Antimicrobial Activity of Thiazolidinone Derivatives

Volume: 8 Issue: 1

Author(s): Ravichandran Veerasamy, Harish Rajak, Krishnan Suresh Kumar and Ram Kishore Agrawal

Affiliation:

Keywords: Thiazolidinones, Antibacterial, Antifungal, Anti-viral, Schiff's reaction, Antimicrobial, nucleoside, NNRTIs, TBZs, SAR, anti-HIV, MT-4 cells, TBZ, minimum inhibitory concentrations, TLC, DMSO, CHCl3, FAB-MS, Cytotoxicity, influenza A H3N2, MDCK, KOS, EC50, CC50

Abstract: A series of 1,3-thiazolidin-4-one derivatives were prepared by the reaction of respective aromatic amine, aromatic aldehyde and thioglycolic acid in dry benzene/toluene. The newly synthesized compounds were characterized on the basis of elemental analysis, IR, 1HNMR and mass spectra. The newly synthesized final compounds were evaluated for their in-vitro antibacterial, antifungal and anti-viral activities. Preliminary results indicated that most of the compounds demonstrated moderate to good antimicrobial activity, comparable to standard drugs. Structure – activity relationship studies revealed that the nature of the substituents at the 2nd and 3rd positions of the thiazolidinone nucleus had a significant impact on the in-vitro antimicrobial activity of this class of potent antimicrobial agents.

Cite this article as:

Veerasamy Ravichandran, Rajak Harish, Suresh Kumar Krishnan and Kishore Agrawal Ram, Synthesis and Evaluation of Antimicrobial Activity of Thiazolidinone Derivatives, Letters in Drug Design & Discovery 2011; 8 (1) . https://dx.doi.org/10.2174/157018011793663958