Abstract
The structural and synthetic aspects related to α-oxyiminophosphorus derivatives are reviewed. This includes their preparation through reactions involving C-N double bond or P-C single bond formation as well as the O-functionalization or transformations at the phosphorus atom of other phosphorus substituted oximes. Moreover the synthetic features of α-oxyiminophosphorus derivatives include the reduction of the oximo group with selective preparation of biologically active α-amino-phosphonate and -phosphinate derivatives, as well as the oxidative transformations on the oxime group, rearrangement versus fragmentation reactions, radical reactions and formation of metal complexes.
Keywords: Iminophosphonates, iminophosphinates, iminophosphonium salts, aminophosphonic acids, Beckmann rearrangement
Current Organic Synthesis
Title: α-Hydroxyiminophosphonate, -phosphinate and -phosphonium Derivatives
Volume: 7 Issue: 6
Author(s): Javier Vicario, Concepcion Alonso, Jesus M. de los Santos and Francisco Palacios
Affiliation:
Keywords: Iminophosphonates, iminophosphinates, iminophosphonium salts, aminophosphonic acids, Beckmann rearrangement
Abstract: The structural and synthetic aspects related to α-oxyiminophosphorus derivatives are reviewed. This includes their preparation through reactions involving C-N double bond or P-C single bond formation as well as the O-functionalization or transformations at the phosphorus atom of other phosphorus substituted oximes. Moreover the synthetic features of α-oxyiminophosphorus derivatives include the reduction of the oximo group with selective preparation of biologically active α-amino-phosphonate and -phosphinate derivatives, as well as the oxidative transformations on the oxime group, rearrangement versus fragmentation reactions, radical reactions and formation of metal complexes.
Export Options
About this article
Cite this article as:
Vicario Javier, Alonso Concepcion, M. de los Santos Jesus and Palacios Francisco, α-Hydroxyiminophosphonate, -phosphinate and -phosphonium Derivatives, Current Organic Synthesis 2010; 7 (6) . https://dx.doi.org/10.2174/157017910794328583
DOI https://dx.doi.org/10.2174/157017910794328583 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Circulating Nucleic Acids in Plasma and Serum: Roles in Diagnosis and Prognosis in Diabetes and Cancer
Infectious Disorders - Drug Targets Identification of Marker Genes for Cancer Based on Microarrays Using a Computational Biology Approach
Current Bioinformatics Oncolytic Tanapoxvirus Expressing Interleukin-2 is Capable of Inducing the Regression of Human Melanoma Tumors in the Absence of T Cells
Current Cancer Drug Targets Evaluation of <sup>177</sup>Lu-EDTMP in Dogs with Spontaneous Tumor Involving Bone: Pharmacokinetics, Dosimetry and Therapeutic Efficacy
Current Radiopharmaceuticals Newer Avenues for the Treatment of Leptomeningeal Carcinomatosis
Central Nervous System Agents in Medicinal Chemistry Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells
Medicinal Chemistry Erlotinib in Glioblastoma - Lost in Translation?
Anti-Cancer Agents in Medicinal Chemistry Flavonoids with Therapeutic Potential in Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry Do Insecticides have Adverse Effects on Reproduction
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Monoclonal Antibodies in the Management of Solid Tumors
Current Topics in Medicinal Chemistry Pharmacogenetics of Estrogen Metabolism and Transport in Relation to Cancer
Current Drug Metabolism Cyclooxygenase-2 Inhibitors: A Painful Lesson
Cardiovascular & Hematological Disorders-Drug Targets An Introduction to the Nutrition and Metabolism of Choline
Central Nervous System Agents in Medicinal Chemistry MET and ALK as Targets for the Treatment of NSCLC
Current Pharmaceutical Design Hypoxic Regulation of Metastasis via Hypoxia-Inducible Factors
Current Molecular Medicine The Role of Angiogenesis Inhibitors in the Management of Melanoma
Current Topics in Medicinal Chemistry ABC Transporters as Potential Targets for Modulation of Drug Resistance
Mini-Reviews in Medicinal Chemistry In Vitro and In Vivo Approaches for Screening the Potential of Anticancer Agents: A Review
Current Drug Discovery Technologies Optimizing Gene Silencing Strategies for Pancreatic Cancer
Current Cancer Therapy Reviews Angiogenesis Inhibitors and Radiation in Multimodality Cancer Therapy: Preclinical and Clinical Studies
Current Angiogenesis (Discontinued)