Guanylation of Amines with Isonitriles in the Presence of Iodine

Author(s): Hui Yu, Meishu Zhang, Wenliang Sun, Yuzhe Li, Rui Gao

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 7 , 2010

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A novel one-pot protocol for the synthesis of substituted guanidines was developed. The reaction involved guanylation of amines with isonitriles in the presence of iodine and sodium bicarbonate. This procedure can be applied to the preparation of various substituted guanidines in moderate to good yields.

Keywords: Substituted guanidine, isonitrile, carbonimidoyl diioide, Henry reaction, desulfurizing reagent, dichloromethane, N, N, N- tris (4-nitrophenyl) Guanidine (3a), NMR, mass spectrometry

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [566 - 570]
Pages: 5
DOI: 10.2174/157017810793362262
Price: $65

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