Diquaternized Curarelike Myorelaxants: Structure and Biological Activity

Author(s): N. F. Salakhutdinov, G. A. Tolstikov.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 13 , 2010

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Abstract:

This review discusses the most active natural and synthetic curarelike compounds demonstrating myorelaxants activity. The data are grouped according to chemical structures, namely, quinoline and isoquinoline myorelaxants, myorelaxants with saturated heterocyclic or alkylamine fragments, myorelaxants with a steroid framework, natural and synthetic alkaloid myorelaxants.

Keywords: Curarelike compounds, natural and synthetic myorelaxants, nondepolarizing and depolarizing substances, diquarternized myorelaxants, diquar-ternized myorelaxants, Strychnos, Chondodendron, curare alkaloids, relax-ant action, linkers, antitumor, anti-HIV, antimalarial, hypotensive, nondepolarizing substances, depolarizing substances, Isoquinoline Myorelaxants, Tubocurarine, Chondodendron tomentosum, Me-nispermaceae, Atracurium, nerve blockers, succinyl choline, tetrahydroisoquinoline chlo-rofumarates, cis-dibenzoquinolizine chlorofu-marates, piperidine, morpholine, indolenine, alkaloid thesine, central cyclobutane ring, anatruxonium, Diplacin, Qualidyl, alkanedicar-bonyl fragment, antagonists of acetylcholine, depo-larizing myorelaxant dithylinum, Sux-amethonium, Imbretyl, Paramyon, diadonium, decadonium, oligodimethylsi-loxanes

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Article Details

VOLUME: 10
ISSUE: 13
Year: 2010
Page: [1248 - 1262]
Pages: 15
DOI: 10.2174/13895575110091248
Price: $65

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