Abstract
Analogous to the “triad of anaesthesia” (hypnosis, analgesia and muscle relaxation), analgesia, prevention or control of delirium, and sedation form the ‘triad’ of intensive care pharmacotherapy to facilitate tolerable mechanical ventilation in the critically ill. As in the triad of anaesthesia, agents used primarily for one of these three purposes have additional effects on the other two. In intensive care practice, sedation should therefore not be considered in isolation, but as part of an integrated strategy aimed at minimising patient distress, maximising the efficiency of mechanical ventilation, and facilitating extubation as soon as possible. This review begins by discussing the pharmacology of the agents primarily targeting each component of the ‘triad of intensive care’ , followed by a review of recent research into how these agents should be optimally combined and administered to achieve the best possible patient outcomes.
Keywords: Hypnotics and sedatives, delirium, analgesia, intensive care, respiration, artificial, anaesthesia, sedation, Analgesics, endotracheal intubation, dysphoria, Pethidine, Opioids, Morphine, Fentanyl, Remifentanil, Hypnotics, Midazolam, Lorazepam, Diazepam, Propofol, Alpha Agonists, Clonidine, Dexmedetomidine, propofol infusion syndrome, SEDCOM, haloperidol, Olanzapine, Risperidione, Muscle Relaxants, Agitation, Pain, ventilation
Current Respiratory Medicine Reviews
Title: Optimal Sedation for the Ventilation of Critically Ill Patients
Volume: 6 Issue: 4
Author(s): Michael C. Reade
Affiliation:
Keywords: Hypnotics and sedatives, delirium, analgesia, intensive care, respiration, artificial, anaesthesia, sedation, Analgesics, endotracheal intubation, dysphoria, Pethidine, Opioids, Morphine, Fentanyl, Remifentanil, Hypnotics, Midazolam, Lorazepam, Diazepam, Propofol, Alpha Agonists, Clonidine, Dexmedetomidine, propofol infusion syndrome, SEDCOM, haloperidol, Olanzapine, Risperidione, Muscle Relaxants, Agitation, Pain, ventilation
Abstract: Analogous to the “triad of anaesthesia” (hypnosis, analgesia and muscle relaxation), analgesia, prevention or control of delirium, and sedation form the ‘triad’ of intensive care pharmacotherapy to facilitate tolerable mechanical ventilation in the critically ill. As in the triad of anaesthesia, agents used primarily for one of these three purposes have additional effects on the other two. In intensive care practice, sedation should therefore not be considered in isolation, but as part of an integrated strategy aimed at minimising patient distress, maximising the efficiency of mechanical ventilation, and facilitating extubation as soon as possible. This review begins by discussing the pharmacology of the agents primarily targeting each component of the ‘triad of intensive care’ , followed by a review of recent research into how these agents should be optimally combined and administered to achieve the best possible patient outcomes.
Export Options
About this article
Cite this article as:
C. Reade Michael, Optimal Sedation for the Ventilation of Critically Ill Patients, Current Respiratory Medicine Reviews 2010; 6 (4) . https://dx.doi.org/10.2174/157339810793563677
DOI https://dx.doi.org/10.2174/157339810793563677 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
6-Oxo-Morphinane Oximes: Pharmacology, Chemistry and Analytical Application
Current Medicinal Chemistry The Vasoactive Role of Nitric Oxide: Physiological and Morphological Aspects
Current Pharmaceutical Biotechnology Clinical and Forensic Aspects of Pharmacobezoars
Current Drug Research Reviews Mechanisms of Esophageal Protection, Gastroprotection and Ulcer Healing by Melatonin. Implications for the Therapeutic use of Melatonin in Gastroesophageal Reflux Disease (GERD) and Peptic Ulcer Disease
Current Pharmaceutical Design The Fabry Cardiomyopathy - Diagnostic Approach and Current Treatment
Current Pharmaceutical Design Impact of Antihypertensive Drug Use on Bone Mineral Density and Osteoporotic Fracture - From an Epidemiological Perspective
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery A Discussion of Natural Rubber Latex Allergy with Special Reference to Children: Clinical Considerations
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Acute Antithrombotic Treatment of Ischemic Stroke
Current Vascular Pharmacology Oxytocin in the Heart Regeneration
Recent Patents on Cardiovascular Drug Discovery VEGF Inhibitors in Metastatic Renal Cell Carcinoma: Current Therapies and Future Perspectives
Current Clinical Pharmacology Peripartum Cardiomyopathy: Current State of Knowledge, New Developments and Future Directions
Current Cardiology Reviews Male Pelvic Pain: Beyond Urology and Chronic Prostatitis
Current Rheumatology Reviews New Pharmacologic Horizons in the Treatment of Benign Prostatic Hyperplasia
Current Drug Therapy Ivabradine: The Hope for a Good Treatment of Ischemic Heart Disease
Current Medicinal Chemistry The Management of Phosphodiesterase-5 (PDE5) Inhibitor Failure
Current Vascular Pharmacology Nitric Oxide: State of the Art in Drug Design
Current Medicinal Chemistry Emerging Treatment Strategies and Potential Therapeutic Targets in Primary Sjogrens Syndrome
Inflammation & Allergy - Drug Targets (Discontinued) A Practical Guide for the Treatment of Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF)
Current Cardiology Reviews Peptides in Oral Diseases
Current Pharmaceutical Design Pharmacological Properties and Therapeutic Possibilities for Drugs Acting Upon Endocannabinoid Receptors
Current Drug Targets - CNS & Neurological Disorders