Synthesis of Cyclodextrin Derivatives of Amino-(thiazolyl) Coumarins as Potential Antimicrobial Agents

Author(s): Ahmed Kamal, S. F. Adil, Jaki R. Tamboli, B. Siddardha, U. S.N. Murthy

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 9 , 2010

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Abstract:

A series of new cyclodextrin linked coumarins was synthesized (12a-g) and evaluated for th ei r antimicrobial activity. All the compounds investigated have shown significant antimicrobial a c t iv i ty against gram-positive and gramnegative bacterial strains as well as a few fungal strains. The compounds exhibited upto 4-fold improved biological activity than their precursors. The results suggest that the improvement in bioavailability is responsible for the enhanced biological activity.

Keywords: Amino-thaizolyl coumarin, Cyclodextrin, Antibacterial, Bioavailability, Coumarins, Antimicrobial agents, Gram-positive, Grame-negative, Cyclodextrin,, Therapeutically active drug, Systemic circulation, Anti-mycobacterium, Hepatitis C RNA synthetase, Coumarin derivatives, Anti-tumour, Anticancer activities, Oligosaccharides, Indomethacin, Prednisolone, Antimicrobial activity, Coumarin-thiazole derivatives, Clotrimazole, Antifungal activity, Standard drug, Lipophilicity, Aqueous Solubility (log S), Antifungal assay, Potato Dextrose Agar, Inhibition zones, Anti-tubercular agents, Poten inhibitors, Leukocyte activation

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Article Details

VOLUME: 7
ISSUE: 9
Year: 2010
Page: [665 - 673]
Pages: 9
DOI: 10.2174/157018010792929559
Price: $65

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