Estrone (E1) Based Esters as Potential Inhibitors of Type 3 17β- hydroxysteroid Dehydrogenase (17β-HSD3) in the Treatment of Hormone-Dependent Prostate Cancer

Author(s): Moniola S. Olusanjo, Sabbir Ahmed

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 9 , 2010

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We report the use of estrone (E1)-based compounds in the search for inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds are good inhibitors of 17β-HSD3 and a number were found to be equipotent to the standard inhibitors used within the current study.

Keywords: 17β-Hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound, Prostate cancer, Estrone, Potential Inhibitors, Estrone (E1)-based compounds, Type 3 (17bHSD3), Standard inhibitors, Biochemical target, Androgen-dependent cancer, Breast cancer, Ester-based derivatives, Non-radioactive steroids, Perkin-Elmer Fourier Transform Paragon, PET polyester, 17b-Hydroxysteroid dehydrogenase, Inhibitory activity, Cycloalkyl based compounds

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Article Details

Year: 2010
Page: [650 - 656]
Pages: 7
DOI: 10.2174/157018010792929496
Price: $65

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