The Relationship Between Inflammation, Platelet Activation and Antiplatelet Resistance

Author(s): Sadik Acikel, Ramazan Akdemir

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
(Formerly Current Drug Targets - Inflammation & Allergy)

Volume 9 , Issue 5 , 2010


Even though there is a strong evidence suggestive of benefits and safety of dual (aspirin plus clopidogrel) antiplatelet therapy, decreased responsiveness or “resistance” to mono- and/or dual antiplatelet therapy has been described in association with an increased thrombotic risk. Various mechanisms contribute to antiplatelet resistance, with abundant production of inflammatory markers being of particular importance. The current review overviews implications of inflammation in antiplatelet resistance.

Keywords: Aspirin resistance, clopidogrel resistance, inflammation, platelets, aspirin, clopidogrel, megakaryocytes, ribonucleic acid, Thrombopoietin binds, adenosine, diphosphate, thromboxane A2, cyclooxygenase, plasminogen, arachidonic acid, P-selectin, matrix metalloproteinase, serine residue, vitamin K, thienopyridine, ticlodipine, P-glycoprotein, Metoprolol, cytochrome P450, polymorphisms, C-reactive protein, coronary syndrome patients, psoriatic arthritis, ankylosing spondylitis, apolipoprotein B, dyslipidemia, hypercholesterolemia, electrophoresis, mass spectrometry, glutathione-S-transferase, thrombogenesis, vascular endothelial growth factor, cilostazol, Diabetes Mellitus

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Article Details

Year: 2010
Page: [364 - 381]
Pages: 18
DOI: 10.2174/187152810793938017
Price: $58

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