Non-Invasive Imaging of the Type 2 Cannabinoid Receptor, Focus on Positron Emission Tomography

Author(s): Nele Evens, Guy M. Bormans

Journal Name: Current Topics in Medicinal Chemistry

Volume 10 , Issue 15 , 2010

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Abstract:

The type 2 cannabinoid receptor (CB2R) is a relatively new target for drug development, as the receptor was only discovered in 1993. The CB2R is mainly expressed in tissues and organs related to the immune system. However, in pathological conditions, mostly inflammatory, a strong upregulation has been observed. Because of its expression in activated microglia, the type 2 cannabinoid receptor might play an important role in pathologies with a neuroinflammatory component. Positron emission tomography provides a sensitive non-invasive imaging technique to study and quantify receptor expression. In this review, the importance of CB2R imaging, the current status and the future possibilities for the development of CB2R PET radioligands are discussed.

Keywords: Type 2 cannabinoid receptor, PET, endocannabinoid, non-invasive imaging

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Article Details

VOLUME: 10
ISSUE: 15
Year: 2010
Page: [1527 - 1543]
Pages: 17
DOI: 10.2174/156802610793176819
Price: $65

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