Synthetic Accesses to 3/5-pyrazole Carboxylic Acids

Author(s): Yves L. Janin

Journal Name: Mini-Reviews in Organic Chemistry

Volume 7 , Issue 4 , 2010


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Abstract:

This review attempts to sum up all the synthetic accesses to 3/5-pyrazole carboxylic acids or esters published, or patented, in the last 120 years. Many of them have demonstrated their robustness as well as quite large scopes. However, a majority are relying on the regioselectivity of reactions such as ketones deprotonations, cyclocondensations or [2+3] cycloadditions. For this reason, the preparation of original 3/5-carboxypyrazoles featuring a structure departing from the inherent regioselectivity of these synthetic accesses could be problematic. Moreover, a large scale synthesis of some 3/5-carboxypyrazoles could be a real challenge. It is thus reasonable to forecast that even more synthetic methodologies should be reported in the future in attempts to meet such requirements.

Keywords: Pyrazoles, side chain oxidation, cyclocondensation reactions, [2+3] cycloaddition reactions, diazomethane, ethyldiazoacetate

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2010
Page: [314 - 323]
Pages: 10
DOI: 10.2174/157019310792246364
Price: $65

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