The Role of Nuclear Factor-κB in Inflammatory Lung Disease

Author(s): Abbas Ali Imanifooladi, Samaneh Yazdani, Mohammad Reza Nourani

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
Formerly Current Drug Targets - Inflammation & Allergy

Volume 9 , Issue 3 , 2010


Nuclear factor-κB (NF-κB) is one of the most important transcription factors; it has a key role in inflammatory and immune responses, cell adhesion, developmental signals, and anti-apoptosis process. Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality worldwide. In this review, we highlight the role of NF-κB in inflammatory lung disease, the strategies which block the activation of NF- κB, and the therapeutic approaches to treating inflammatory lung disease.

Keywords: Asthma, cell adhesion, COPD, inflammatory lung disease, NF-κB, therapeutic approach

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Article Details

Year: 2010
Page: [197 - 205]
Pages: 9
DOI: 10.2174/187152810792231904
Price: $65

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