Synthesis and Biological Evaluation of A Series of (Benzo[d]thiazol-2-yl) Cyclohexanecarboxamides and (Benzo[d]Thiazol-2-yl)Cyclohexanecarbothioamides

Author(s): Nguyen Hai Nam, Phan Thi Phuong Dung, Phuong Thien Thuong, Tran Thi Hien

Journal Name: Medicinal Chemistry

Volume 6 , Issue 3 , 2010


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Abstract:

A series of benzothiazole derivatives including N-(benzo[d]thiazol-2-yl)cyclohexanecarboxamides (2a-g) and N-(benzo[d]thiazol-2-yl)cyclohexancarbothioamides (3b-d) have been synthesized and evaluated for cytotoxic and antimicrobial activities. Two compounds including N-(6-ethoxybenzo[d]thiazol-2-yl)cyclohexanecarboxamide (2c) and N-(6- ethoxybenzo[d]thiazol-2-yl)cyclohexanecarbothiamide (3c) demonstrated significant cytotoxicity against three cancer cell lines (A549, MCF7-MDR and HT1080) while most of compounds exhibited moderate inhibitory effects on the growth of Staphyllococcus aureus and some other fungi.

Keywords: Benzothiazole, synthesis, cytotoxicity, antibacterial, antifungal

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2010
Published on: 01 March, 2012
Page: [159 - 164]
Pages: 6
DOI: 10.2174/1573406411006030159
Price: $65

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