Corticosteroids in Sepsis: Pathophysiological Rationale and the Selection of Patients

Author(s): Jorge Ibrain Figueira Salluh, Fernando Augusto Bozza, Andre Miguel Japiassu, Hugo Caire Castro Faria Neto, Patricia Torres Bozza, Pedro Povoa

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 10 , Issue 3 , 2010

Become EABM
Become Reviewer
Call for Editor


Corticosteroids have been proposed for decades as adjunctive therapy of severe infections. These drugs have complex mechanisms of action involving anti-inflammatory and vasoactive properties. However, due to discordant results from clinical studies, the use of corticosteroids to treat patients with severe infections is still a matter of intense debate in the scientific and medical community. In the present article, we review the underlying mechanisms related to the potential benefits of corticosteroids and their impact on clinical management of severe sepsis.

Keywords: Bacterial infections, glucocorticoids, sepsis, septic shock, therapeutics

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [266 - 273]
Pages: 8
DOI: 10.2174/187153010791936865
Price: $65

Article Metrics

PDF: 9