Neurohypophyseal Dysfunction During Septic Shock

Author(s): Alexandre Giusti-Paiva, Michael Brian Santiago

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 10 , Issue 3 , 2010

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Septic shock is characterized by vasodilation and hypotension despite increased vasoconstrictors. While nitric oxide is known to be responsible for vasodilation, failure of vascular smooth muscle to constrict may be due in part to low plasma levels of vasopressin, a neurohypophyseal hormone. In the initial phase of septic shock, vasopressin concentration usually increases but then decreases to a significantly lower concentration after onset of septic shock. In this review, we discuss the neural mechanisms for the regulation of vasopressin secretion during septic shock.

Keywords: Endotoxic shock, hypotension, osmolality, septic shock, vasopressin

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Article Details

Year: 2010
Page: [247 - 251]
Pages: 5
DOI: 10.2174/187153010791936838
Price: $65

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