Abstract
Two lithocholic acid (LCA) derivatives — mono- and diesters (newly synthetised) — are studied for their main conformational preferences, by Raman spectroscopy coupled to theoretical (DFT) methods. Raman bands characteristic of each compound were assigned, allowing an accurate and rapid identification of this kind of systems. The conformational preferences of the LCA diester were related with its ability to function as a model for artificial receptors, displaying a tailored structural profile.
Keywords: Lithocholic acid derivatives, Artificial receptors, Conformational analysis, Raman spectroscopy
Letters in Drug Design & Discovery
Title: Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study
Volume: 7 Issue: 8
Author(s): F.M.F. Roleira, E.J. Tavares da Silva, Rui A. Carvalho and M.P.M. Marques
Affiliation:
Keywords: Lithocholic acid derivatives, Artificial receptors, Conformational analysis, Raman spectroscopy
Abstract: Two lithocholic acid (LCA) derivatives — mono- and diesters (newly synthetised) — are studied for their main conformational preferences, by Raman spectroscopy coupled to theoretical (DFT) methods. Raman bands characteristic of each compound were assigned, allowing an accurate and rapid identification of this kind of systems. The conformational preferences of the LCA diester were related with its ability to function as a model for artificial receptors, displaying a tailored structural profile.
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Cite this article as:
Roleira F.M.F., Tavares da Silva E.J., A. Carvalho Rui and Marques M.P.M., Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study, Letters in Drug Design & Discovery 2010; 7 (8) . https://dx.doi.org/10.2174/157018010792062731
DOI https://dx.doi.org/10.2174/157018010792062731 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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