One-Pot Four-Component Synthesis of 3-(1,3,4-Thiadiazol-2-ylamino)-3-arylpropanoates

Author(s): Zheng Li, Yanbo Li, Hongfang Cai, Jun Xu, Jinghong Shi

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 6 , 2010


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Abstract:

A novel one-pot four-component synthetic method for 3-(1,3,4-thiadiazol-2-ylamino)-3-arylpropanoates by condensation of 2-amino-1,3,4-thiadiazoles, aldehydes, Meldrums acid and aliphatic alcohols catalyzed by p-toluenesulfonic acid was described. The protocol has advantages of mild conditions, high yield and simple work-up procedure.

Keywords: β-Amino acid ester, condensation, four-component synthesis, Meldrum's acid, 1,3,4-thiadiazole, 3-(1,3,4-thiadiazol-2-ylamino)-3-arylpropanoate

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Article Details

VOLUME: 7
ISSUE: 6
Year: 2010
Published on: 01 March, 2012
Page: [467 - 471]
Pages: 5
DOI: 10.2174/157017810791824964
Price: $65

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