Metal Triflates: Efficient Catalysts for Oxa-Pictet-Spengler Reaction

Author(s): Benaissa Bouguerne, Christian Lherbet, Michel Baltas

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 6 , 2010

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A screening of different metal triflates as catalysts was performed to get isochromans through an oxa-Pictet- Spengler reaction. Good to high yields were obtained for various aliphatic or aromatic aldehydes and β-arylethanols. A mechanism involving catalysis by in situ liberated triflic acid to catalyse the isochroman ring formation is proposed.

Keywords: Metal triflate, oxa-Pictet-Spengler, catalysis

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Article Details

Year: 2010
Published on: 01 March, 2012
Page: [420 - 423]
Pages: 4
DOI: 10.2174/157017810791824883
Price: $65

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