Abstract
Despite the beneficial effect of the HAART, adverse reactions and drug interaction have been observed. Abnormalities in lipid and glucose metabolism make HIV-positive patients to high risk for the development of coronary heart disease and diabetes, respectively. Besides adverse reactions, drug interaction with other medication can also be observed. In fact, drug interaction may interfere in the periodontal therapy in HIV-infected individuals. For instance, fluconazole, ketoconazole, itraconazole, metronidazole, ciprofloxacin, midazolam and triazolam can interact with some antiretroviral medications, such as zidovudine, nevirapine and ritonavir. The aim of the current study was to show to periodontists and general dental practitioners the importance of understanding the drug interaction in HIV-infection in order to establish a better control during periodontal treatment.
Keywords: HAART, periodontitis, HIV
Mini-Reviews in Medicinal Chemistry
Title: Drug Interactions During Periodontal Therapy in HIV-Infected Subjects
Volume: 10 Issue: 8
Author(s): L. de S. Goncalves, B.M.L. Goncalves, M.A.C. de Andrade, F.R.F. Alves and A.S. Junior
Affiliation:
Keywords: HAART, periodontitis, HIV
Abstract: Despite the beneficial effect of the HAART, adverse reactions and drug interaction have been observed. Abnormalities in lipid and glucose metabolism make HIV-positive patients to high risk for the development of coronary heart disease and diabetes, respectively. Besides adverse reactions, drug interaction with other medication can also be observed. In fact, drug interaction may interfere in the periodontal therapy in HIV-infected individuals. For instance, fluconazole, ketoconazole, itraconazole, metronidazole, ciprofloxacin, midazolam and triazolam can interact with some antiretroviral medications, such as zidovudine, nevirapine and ritonavir. The aim of the current study was to show to periodontists and general dental practitioners the importance of understanding the drug interaction in HIV-infection in order to establish a better control during periodontal treatment.
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Cite this article as:
de S. Goncalves L., Goncalves B.M.L., de Andrade M.A.C., Alves F.R.F. and Junior A.S., Drug Interactions During Periodontal Therapy in HIV-Infected Subjects, Mini-Reviews in Medicinal Chemistry 2010; 10 (8) . https://dx.doi.org/10.2174/138955710791572451
DOI https://dx.doi.org/10.2174/138955710791572451 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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